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Interestingly, some evidence supports the hypothesis that STK11/LKB1 co-mutation in KRAS mutated NSCLC could represent a negative predictive factor for immunotherapy (144)

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PANORAMA and a small study from Japan that examined the efficacy and tolerability of combination therapy with inhaled NAC and pirfenidone versus pirfenidone alone had findings that suggested more rapid disease progression in the group that received combination therapy [24]

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